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Predator: Xenogenesis formed the Predator component of Dark Horse's franchise-crossing Xenogenesis event in 1999, and was released in conjunction with Aliens: Xenogenesis and Aliens vs. Predator: Xenogenesis. The three loosely interconnected stories all share a similar new art and storytelling style that was a departure from the those typically found in the series until then.
The conclusion of Xenogenesis also marked the beginning of a ten-year hiatus in the Predator comics line, during which time no new Predator comics would be released. It was preceded by Predator: Homeworld, and when the Predator line eventually resumed, it was followed by the Predator (2009 short story)